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🖱️ Elevate your workflow with comfort, precision, and freedom — the mouse that works as hard as you do!
The Nulea MD280 is an ergonomic vertical wireless mouse featuring dual-mode Bluetooth and 2.4G connectivity, 4 adjustable DPI levels (800-2400), and a rechargeable battery lasting up to 260 days per charge. Designed to reduce wrist strain with a dedicated pinky rest and silent click buttons, it’s ideal for professionals seeking comfort, precision, and long-lasting performance across multiple devices.








| ASIN | B0DC6JYJ9J |
| Additional Features | Soundless |
| Antenna Location | Indoor |
| Are Batteries Included | No |
| Are Batteries Required | Yes |
| Battery Average Life | 8.53 months |
| Best Sellers Rank | #342 in Computer Mice |
| Brand | Nulea |
| Built-In Media | USB cable |
| Button Quantity | 5 |
| Color | Black |
| Compatible Devices | Personal Computer, Tablet |
| Connectivity Technology | Bluetooth |
| Customer Reviews | 4.4 out of 5 stars 743 Reviews |
| Enclosure Material | Plastic |
| Finish | Matte |
| Hand Orientation | Right |
| Item Weight | 0.3 Kilograms |
| Manufacturer | Nulea |
| Mfr Part Number | MD280 |
| Minimum Required Operating System Version | Windows 10 |
| Model Name | MD280 |
| Model Number | MD280 |
| Mouse Maximum Sensitivity | 2400 Dots per Inch |
| Movement Detection | Optical |
| Movement Detection Technology | Optical |
| Number of Buttons | 5 |
| Operating System | Windows |
| Power Source | Battery Powered |
| Range | 33 feet |
| Special Feature | Soundless |
| Style Name | Modern |
| Theme | Gaming |
| Unit Count | 1.0 Count |
| Warranty Description | 12 months |
J**G
Best Value Vertical Wireless Mouse
Great Mouse! I love the seamless switching between devices in bluetooth or receiver, and it is very comfortable to hold. Helped my wrist pain a ton. USB c charging also lasts a long time. I charged it maybe 3 times in the past 8 months or so and I use it for work. It suffered a lot of drops and was still functional. The very last drop made my scroll wheel sticky, but everything otherwise works. Great bang for buck. Would buy again in a heartbeat. EDIT: I FIXED THE SCROLL WHEEL. I lifted the mouse button and used a screwdriver to lift under a circular groove near the center of the wheel. It's still truckin.
Y**2
Amazing ergonomic mouse
It's amazing, comfortable and love the color and the versatile of connections. Easy to connect just a click one button.
J**R
My MX Vertical replacement (for now)
I have Med-Large hands which I think is important to remember when you read this review. Hand size is very important when you're considering vertical mice. For me, I switched to vertical mice due to carpal tunnel a couple years ago, and it really helped to eliminate it. I went to Best Buy and tried both the Logitech Lift and MX Vertical. The Lift is for smaller hands and I didn't like the feel of it. So I bought the larger MX Vertical despite the $100 pricetag with the hope that it'd help my carpal tunnel. It did, but unfortunately, now its suffering from the double click issue that apparently is a feature of Logitech mice. So I began the hunt for another vertical mouse that didn't cost +$100. I knew I wanted one that was for Medium to Large hands, so I’ve tried 5 different ones that said they were for larger hands or had similar measurements to the MX Vertical. For reference the dimensions shown on box are 4.8in x 3in x 3.1in Pros: Mouse is definitely larger and fits my hand nicely. The bubble shape fills my palm nicely. The clicks are quiet and soft yet tactile. Scroll wheel feels fine and not flimsy. Has a rechargeable battery (which technically is a con if it quits working). Price was very competitive at $17. The DPI goes to 2400. Cons: The bottom “slip” pads sometimes catch on my mouse pad. The clicks aren’t as satisfying as the ProtoArc EM11 or Nulea M510 and I definitely like the scroll wheel better on the M510. In the end, I will probably keep this one as my replacement for the MX Vertical. Even if the mouse might be somewhat inferior, $17 vs $117 is too big of a price difference to ignore. And for me at least, the shape is the best fit for my large hands. I will say that I tend to agree with the other reviewer that the Nulea M510 is an upgrade to this mouse. The clicks are better and the scroll wheel is nicer. However, it is shaped differently with a curve and less of a bubble shape and more of a gentle slope. For me at least with the M510, my hand tended to slide down the slope and end up resting on the mouse pad which so far doesn’t seem to happen with this one. Is it perfect? No. Will it work for me without breaking the bank? Definitely.
S**A
For large hand, slightly heavy.
High quality, works great, a little on the heavy side. Comfortable for a large hand. I have a smaller hand and it's difficult to lift the mouse while using.
P**B
My new favorite brand, new favorite mouse!
This is my second Nulea mouse, purchased this as the previous one was showing its age after 2 years of use. Does a mouse need to be changed as soon? Depends on the cat you have! For the price, much prefer buying this over and again instead of some of the more expensive mice on the market. My last mouse and this are both perfect for big hands - it's not a pinch grip, but like holding a nice and girthy burrito 😂 The matte finish, a little dimple by the thumb makes for a very relaxed hold. Also, ALL the buttons are QUIET! The clicks, forward-back, dpi setting are quiet buttons. The button to toggle between devices is at the top, making it easy to switch, especially when working on multiple systems at the same time. The charge lasts a long time - I like that it's USB-C rechargeable, and I don't have to keep going through batteries. Great mouse, will continue to buy from this brand. It's not expensive, so it doesn't break the bank if the cat decides to have a mouse chase (what happened with my last Nulea mouse! 😆)
L**R
Only charged 2 times in over a year of heavy use!
Purchased February 15 2025. Use it Every day, 5 days a week 12 or more hours those days. Today, 18 April 2026 I’m charging it for the Second time. Very quiet, easy on the wrist. I have large hands, purchased this because larger than the Leakey that was dead in less than a year + often charging. If Nulea were to offer a larger one I would roll with that. Very pleased with this.
D**O
Defective Battery, but Excellent Customer Support
I purchased this mouse with high expectations, but unfortunately it stopped holding a charge shortly after I received it. The mouse works perfectly while connected via USB cable and also connects correctly through Bluetooth and the USB dongle. However, once disconnected from the charging cable, it immediately turns off, even after charging it for several hours. It seems the internal battery was defective. That said, I want to highlight that customer support was responsive and professional. After I shared a video showing the issue, they initially offered to send a replacement. Later, they informed me that their replacement system does not support shipping outside the USA, so they issued a full refund instead. The refund was processed promptly and handled in a transparent manner.
M**Z
Must Buy.
This is a must have!! I have purchased this for myself and as gifts for coworkers! Great wrist support and amazing quality.
J**R
A Lightweight and Excellent Wrist-Friendly Vertical Mouse!
A Lightweight and Excellent Wrist-Friendly Vertical Mouse. I’ve been using another model, the M513, but this MD280 model has a slightly wider grip compared to the M513. However, the M513 requires two batteries, while the MD280 uses USB Type-C for charging and doesn’t need batteries at all, making it very lightweight and excellent. Additionally, you can switch to a wired connection by plugging in a cable, allowing you to connect it to your computer. Since this vertical mouse is designed to be extremely lightweight, I think the MD280 is a great choice for those who prefer a slightly wider grip and have issues with batteries. For those who have been using a regular mouse and are experiencing wrist pain, I highly recommend this vertical mouse. It significantly reduces pain, and it’s much better than a regular mouse. From my experience using both models, I believe that women with smaller hands might prefer the M513 because it has a slightly thinner grip than the MD280. However, this is something you can get used to, and once you try the MD280, you’ll notice its overwhelming lightness. Compared to the M513, which has two batteries, the MD280 is much lighter since it doesn’t require batteries. This lightweight design could make a difference during prolonged use. For anyone who has never used a vertical mouse and is dealing with wrist pain from a regular mouse, or for those who are debating between a vertical mouse and a trackball, I recommend trying the vertical mouse. I used a vertical mouse for the first time this time, and I experienced no wrist pain at all. With a regular mouse, just clicking caused pain in my index finger, thumb, and wrist due to tendonitis, but with the vertical mouse, the pain was reduced to about 1/2, 1/3, or even 1/4. I’ve also used a trackball in the past, but that caused finger pain. However, the vertical mouse didn’t hurt as much as either a regular mouse or a trackball. The price is also very reasonable. Therefore, I highly recommend the vertical mouse.
T**S
Confortable
La souris est exclusivement pour droitier, ce qui peut sembler logique, mais important à préciser avant l’achat. Sous la souris, on trouve une petite trappe permettant de ranger le dongle USB, ainsi que le bouton d’allumage. Elle se recharge en USB-C, et l’autonomie est excellente : je l’utilise tous les jours et je ne la charge qu’une fois par mois, ce qui est un vrai point fort. Elle possède un bouton de réglage des DPI, permettant d’ajuster rapidement la vitesse du curseur en fonction des tâches effectuées. La prise en main est un peu surprenante au début, car la main n’est pas posée à plat, mais inclinée dans un axe plus naturel. La différence se ressent surtout en reprenant une souris classique, où l’on réalise à quel point cette position est plus ergonomique. Je travaille en flex office, donc avec des bureaux de différentes couleurs, et sans tapis de souris. Aucun problème de détection, le capteur fonctionne parfaitement sur toutes les surfaces testées. L’essayer, c’est l’adopter.
A**S
Surprenante pour le prix
Cette souris ergonomique Nuléa vendue à petit prix m’a très agréablement surpris. Elle possède en effet plusieurs fonctions rarement accessibles à ce tarif, comme la double connexion Bluetooth / 2,4 GHz, ou encore son fonctionnement sur batterie rechargeable. Son design s’inspire d’une des best-sellers d’une célèbre marque de souris, et si les finitions sont logiquement moins bonnes, l’ensemble reste très correct. La prise en main est agréable (pour ceux à qui les souris verticales conviennent) et le bouton permettant le switch entre les différents ordinateurs reliés est bien pratique pour basculer de l’un à l’autre facilement, sans avoir à retourner la souris comme c’est souvent le cas. Le capteur 2400 dpi est suffisant pour mon usage bureautique et doit pouvoir faire l’affaire pour quelques jeux peu exigeants. Au final, pour un peu plus de 20 euros au jour de cet avis, difficile d’avoir quelque chose à redire de cette souris.
N**N
Would recommend
I’ve used this style of mouse for the last 5 or so years and prefer it. This one seems a little thicker than other ones I’ve used so I’m not sure how comfortable you’d find it if you had small hands. Like: Easy connections and multiple ways to connect (however unfortunately it won’t connect to my work laptop no matter how much I try. No issues connecting to my personal computers or my other work computer though so not blaming this one on the mouse). Battery lasts for soooo long and you’re able to charge it while you use it. Don’t really have any dislikes. The scroll wheel might be a little touchy. Often when I’m scrolling, I’ll push the wheel down a bit and activate that other thing that lets you scroll by moving the mouse up/down/sideways. It really an issue though and I’m not taking any points off for it.
G**N
Ratón inalámbrico ergonómico que evita lesiones
Hace unos meses me empezó a doler el hombro derecho. Fui al fisioterapeuta y me confirmó que por mi trabajo de oficina tenía una inflamación crónica provocada por el uso del ratón. Me dijo que para evitar que fuera a mas, tenía que empezar a usar un ratón vertical que fuera lo mas ergonómico posible y con el tiempo y mas sesiones de fisioterapia se iría corrigiendo. He tenido la oportunidad de adquirir este ratón de la marca Nulea y no lo he dudado ni un segundo. Después de ponerlo a prueba durante mas de una semana y con una media de 9 horas de trabajo solo puedo decir maravillas sobre el. Estas son las principales características que me gustaría remarcar, por si ayuda a otros compradores. - La comunicación es inalámbrica mediante bluetooth. Se puede hacer directamente con el ordenador si lleva integrado bluetoooth o bien a trasvés del USB que lleva oculto dentro del propio ratón y que está tapado por una tapa magnética. Simplemente hay que tocar un botón para escoger el modo. - Es tremendamente ergonómico y fácil de usar. Se ajusta perfectamente a la palma de la mano y los botones están a un a distancia cómoda de pulsar. - La tecnología de funcionamiento es óptica y no laser, por lo que puede funcionar el cualquier superficie con una precisión optima. - Se puede configurar la velocidad del movimiento del puntero mediante uno de los botones (800/1200/1600/2400 DPIs). - Tiene 5 botones de funcionamiento y una rueda de desplazamiento. Se nota que los botones actúan al pulsarlos, pero de una manera muy silenciosa. - La batería integrada dura una barbaridad. - El cable de carga es un USB de tipo C. Conclusión: Este ratón vertical es tremendamente ergonómico y fácil de usar. Es un accesorio de ordenador muy útil para evitar dolencias producidas por una mala postura provocada por el uso de un ratón inadecuado.
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