---
product_id: 5519535
title: "Doctor's Best SAM-e 400 mg, Vegetarian, Gluten Free, Soy Free, Mood and Joint Support, 30 Enteric Coated Tablets"
brand: "doctor's best"
price: "€ 116.02"
currency: EUR
in_stock: true
url: https://www.desertcart.nl/products/5519535-doctors-best-sam-e-400-mg-vegetarian-gluten-free-soy
store_origin: NL
region: Netherlands
---

# Vegan Friendly Joint Comfort Cognitive Boost Doctor's Best SAM-e 400 mg, Vegetarian, Gluten Free, Soy Free, Mood and Joint Support, 30 Enteric Coated Tablets

**Brand:** doctor's best
**Price:** € 116.02
**Availability:** ✅ In Stock

## Summary

> Unlock Your Best Self with SAM-e! 🌟

## Quick Answers

- **What is this?** Doctor's Best SAM-e 400 mg, Vegetarian, Gluten Free, Soy Free, Mood and Joint Support, 30 Enteric Coated Tablets by doctor's best
- **How much does it cost?** € 116.02 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.nl](https://www.desertcart.nl/products/5519535-doctors-best-sam-e-400-mg-vegetarian-gluten-free-soy)

## Best For

- doctor's best enthusiasts

## Why This Product

- Trusted doctor's best brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Pure and Clean:** Pharmaceutical grade, Non-GMO, Gluten Free, Vegan.
- • **Backed by Science:** 18 controlled trials over 40 years validate effectiveness.
- • **Elevate Your Mood:** Proven to enhance mood and cognitive health.
- • **Liver Detox Dynamo:** Promotes liver health and detoxification.
- • **Joint Mobility Champion:** Supports comfort and mobility for an active lifestyle.

## Overview

Doctor's Best SAM-e 400 mg is a vegetarian, gluten-free supplement designed to enhance mood, support cognitive health, and promote joint comfort. With a proven track record from 18 controlled trials over 40 years, this pharmaceutical-grade product is perfect for those seeking a clean, effective solution for mental and physical well-being.

## Description

SAM-e 400 mg, Vegetarian, Gluten Free, Soy Free, Mood and Joint Support, 30 Enteric Coated Tablets

## Features

- Doctor's Best SAMe Double Strength is proven to enhance mood and promote cognitive health
- SAMe is essential for the healthy metabolism of the major brain transmitters dopamine, serotonin and norepinephrine
- SAMe has been proven to promote joint comfort and mobility and supports liver health and detoxification
- SAMe's effectiveness has been proven with 18 controlled human trials published over 40 years
- Pharmaceutical grade, Non-GMO, Gluten Free, Vegan

## Product Details

- **Brand:** Doctor's Best
- **Flavor:** Unflavored
- **Primary Supplement Type:** multivitamin
- **Unit Count:** 30 Count
- **Item Form:** Tablet
- **Item Weight:** 0.17 Pounds
- **Item dimensions L x W x H:** 1.75 x 3.25 x 6.25 inches
- **Diet Type:** Vegetarian, Gluten Free
- **Product Benefits:** Detoxing
- **Age Range (Description):** Adult

## Images

![Doctor's Best SAM-e 400 mg, Vegetarian, Gluten Free, Soy Free, Mood and Joint Support, 30 Enteric Coated Tablets - Image 1](https://m.media-amazon.com/images/I/717Si9dY1oL.jpg)

## Available Options

This product comes in different **Flavor Name, Size** options.

## Questions & Answers

**Q: Is each tablet packaged in foil?**
A: The tablets are in a ten count foil blister pack. Each pill has it's own sealed compartment. I am an RN and this is like medical grade packaging. Safe.

**Q: Could this cause you to feel warm or hot and sometimes dizziness?**
A: SAM-e, especially when combined with other medications, has a potential to contribute to Seratonin Syndrome, which can cause temperature disregulation and dizziness. This is a supplement that effects the function of your brain and neural pathways. Please make sure you use it as directed and preferrably under the care of someone who is knowledgeable on the subject if you have not done your own research. If any adverse reactions occur, stop taking the supplement and please talk to your doctor about it. There is the potential for very bad reactions if Seratonin builds up too much. 

Every person's brain is unique and will react in different ways. Nothing involved in brain support supplements are a one-size-fits-all.

**Q: how long does it take to start working**
A: I have taken SAM-e for 15 years very successfully. It has never failed to work for me, unlike Rx antidepressants and other supplements (like St John's Wort). In the last year I have increased from 1 400 mg pill daily to 2. I'm in my 60s and i just seem to feel better with more. (It is also anti-aging because it helps correct the mistakes that accumulate in our DNA). In my experience SAM-e works very quickly. If I need a boost, I take an extra dose and I feel better within 1-2 hours. You can take up to 1600 mg in a day (four 400 mg pills) with no problem. If I know I'm going to have a stressful day I will head off problems by taking 2 upon awakening, and then 1-2 more later in the day, when I can be sure of an empty stomach. It's important to take SAM-e at least 30 minutes before food, or 2 hours after, for best absorption.

**Q: How do these compare to nature made? That's my usual.**
A: For me, I like Nature Made so much better. Nature Made worked for my husband and I. We switched to these in an effort to save money and within two weeks of the switch we both started hurting again. Also these came with several of the bubbles punctured and the pills were different colors, within the pack. If you read some of the recent reviews, you’ll see others had some of the same issues and far as punctured blister packs and color changes within the box. We switched back to Nature Made, which was the brand our Orthapedic doctor had recommended.

## Frequently Bought Together

- Doctor's Best SAM-e 400 mg, Vegetarian, Gluten Free, Soy Free, Mood and Joint Support, 30 Enteric Coated Tablets
- Doctor's Best Vitamin C with Q-C, Immune Support, Non-GMO, Gluten Free, Soy Free, Vegan 360 Veggie Caps

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*Product available on Desertcart Netherlands*
*Store origin: NL*
*Last updated: 2026-03-03*