Would this work for connecting a single footswitch output jack to separate reverb and gain jacks on the back of my amp?

Unless your footswitch output jack can pick up both sides of a stereo plug, you would be better off getting a Y cable that has mono plugs at all three ends.

with this I'm able to line out my guitar amp into 2 channels on my mixer? correct?

yes, usually the headphone output on whatever to individual inputs in a mixer, just be careful about the boost in signal

Would this connect the L/R outputs of a synth to a single input on an audio interface?

Yes, as long as the audio interface has a stereo input jack. You see that one end has 3 rings ... that means it's connecting a Left channel/Right channel/Ground connections all in one male 1/4" jack.

4x12 cabinet with 2-4ohm stereo inputs , amp has only 1-4ohm mono output, will this splitter work without damage to the amp ?

Don't do it. You need to use a speaker cable for a connection between a guitar amp and speaker cabinet, otherwise yes you can cause damage.

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🎛️ Split your sound, not your style.

DURABLE BUILD - Robust round cable with reliable connectors built to last through gigs and sessions
COMPACT 3 FOOT LENGTH - Perfect balance of reach and minimal clutter in your audio rig
VERSATILE AUDIO INSERT - Ideal for send/return loops, effects chains, and patch bay setups—upgrade your sound workflow
PLUG AND PLAY SIMPLICITY - Male-to-male design ensures instant compatibility with your gear—no adapters needed
PRO GRADE SIGNAL SPLITTING - Effortlessly split stereo TRS into dual mono TS for professional audio routing

The Tisino 3-foot 1/4 inch TRS to dual 1/4 inch TS Y-Splitter Cable is a professional-grade insert cable designed to convert stereo signals into dual mono outputs. Featuring durable male-to-male connectors and a compact, flexible design, it’s perfect for audio engineers and musicians looking to streamline their send/return or effects chain setups with reliable, high-quality signal routing.

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Brand	Tisino
Connector Gender	Male-to-Male
Shape	Round
Net Quantity	1.0 Count
Item Weight	0.13 Kilograms
Number of Items	1
Outer Material	Other
Manufacturer	TISINO
Model	TSN9518
Product Dimensions	15.24 x 12.7 x 1.52 cm; 130 g
Item model number	TSN9518
Batteries Included	No
Batteries Required	No
Item Weight	130 g

Tisino 1/4 inch TRS Stereo to Dual 1/4 inch TS Mono Y-Splitter Cable Send and Return Insert Cable Patch Cord - 3 feet-Black

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